Leptin and energy availability
The permission signal from fat to brain, what replacing it does in children who cannot make it, why adding more does nothing for everyone else, the one approved product's contraindication, and the other adipose signals — adiponectin, amylin and PPAR-γ as the fat-or-bone switch.
Leptin is made by fat tissue and read by the hypothalamus. It reports how much stored energy exists, and expensive processes are gated on that report. It is permissive: it does not drive growth, but allows it when energy stores are adequate.
In this article
- What replacing it does
- Opposite effects on bone
- Resistance in obesity
- Adiponectin
- Amylin
- PPAR-γ and marrow fat
- Compounds
- Summary
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Educational content, not medical advice. Nothing here is a recommendation to take or stop taking anything — talk to a doctor about your own situation.