IGF-1 and IGF-1R
The growth factor that does most of the work at the plate, why almost none of it circulates free, and what happens when it is given as a drug.
Growth hormone sets the pace, mostly by inducing IGF-1. IGF-1 is the molecule that reaches the chondrocyte, binds its own receptor and drives proliferation in the columns and the final stage of the enlargement that produces most of a bone's length (see mTORC1 and chondrocyte volume).
In this article
- Compounds
- IGF-1R inhibitors
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Educational content, not medical advice. Nothing here is a recommendation to take or stop taking anything — talk to a doctor about your own situation.