GnRH and pubertal timing

The switch above the sex steroids, the one placebo-controlled trial that measured adult height, and what it cost in bone density to gain four centimetres.

GnRH and puberty: the hypothalamus releases GnRH in pulses, the pituitary answers with LH and FSH, the gonads make sex hormones, and those drive the growth spurt and then close the growth plates. HypothalamusPituitaryGonadsGrowth platesGnRH pulsesLH, FSHsex hormonesspurt, then close

Oestrogen covers the hormone that closes the plate, with the enzyme that makes it and the receptor it binds. This article covers the switch above both: the hypothalamic signal that decides when sex steroids arrive.

In this article

  • What sets the timing
  • The trial
  • Precocious puberty
  • Compounds
  • Summary

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Educational content, not medical advice. Nothing here is a recommendation to take or stop taking anything — talk to a doctor about your own situation.