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FGF23 and phosphate

How a hormone made in bone sets the body's phosphate level, why too much of it widens the growth plate instead of turning it into bone, and what the antibody that blocks it did in children.

HormonesUpdated

6 min read16 sources

FGF23 and phosphate: bone makes FGF23, the kidney reads it through α-Klotho and FGFR1 and sends phosphate out in the urine, and chronically low phosphate leaves the hypertrophic zone piled up instead of turned to bone. bonekidneyKlothoFGFR1phosphate outno active vit DBone to kidneyPhosphate downPlate piles upread through Klotholost in the urineno bone under it

Most fibroblast growth factors act locally. FGF23 is made in bone and read in the kidney, and the specificity comes from a co-receptor.

In this article

  • What it does once it arrives
  • Why chronic low phosphate widens the plate
  • The two inherited excesses
  • Hypophosphatasia, the opposite failure
  • Compounds
  • Summary

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Educational content, not medical advice. Nothing here is a recommendation to take or stop taking anything — talk to a doctor about your own situation.