GrowTallest

AXL and BGB324

The receptor that holds osteoblasts back from maturing, the Isg15 and Erk axis below it, and what blocking it with BGB324 did to bone.

Matrix and boneUpdated

4 min read2 sources

Axl holds the bone-building cell back: Isg15 stays low, Erk stays quiet and maturation is slow. BGB324 blocks Axl, Isg15 rises, Erk stays on, and trabecular bone thickens. Gas6AxlIsg15 ↓p-Erk1/2 ↓AxlBGB324Isg15 ↑p-Erk1/2 ↑Axl onAxl blockedslower maturationmore trabecular bone

A receptor tyrosine kinase of the TAM family — Tyro3, Axl, Mer — activated by its ligand Gas6 and signalling through PI3K/AKT and MAPK. It is well studied in cancer, immune regulation and vascular biology, and its role in bone went largely unexamined until an unbiased RNAi screen across the mouse kinome picked it out as a negative regulator of osteoblast differentiation.

In this article

  • What blocking it does
  • Erk and mechanical load
  • Compounds

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